As humans, we've all learned to go without to some extent or another. So, outside of the basics of food, water, and shelter, we can still manage to get by. I found, however, that once you add desire or want to the equation, things get (or seem to get) a significantly trickier.
Like with most things, I haven't got an answer. All I know is that if I could somehow flip whatever internal switch is responsible for making us want, well, then my life would probably be fantastic. Even if it wasn't, at least I wouldn't know any better.